最新指南连载5双语2016RCO
2018-5-15 来源:不详 浏览次数:次4.3Whatbloodtestsshouldbeperformedinpostmenopausalwomenwithovariancysts?
4.3绝经后卵巢囊肿女性应该做哪些血液检查?
4.3.1CA
CAshouldbetheonlyserumtumourmarkerusedforprimaryevaluationasitallowstheRiskofMalignancyIndex(RMI)ofovariancystsinpostmenopausalwomentobecalculated.
由于检测CA可计算出绝经后妇女卵巢囊肿恶性风险指数(RMI),所以CA应该被作为唯一的血清肿瘤标志物用于初步评估。
CAlevelsshouldnotbeusedinisolationtodetermineifacystismalignant.Whileaveryhighvaluemayassistinreachingthediagnosis,anormalvaluedoesnotexcludeovariancancerduetothenonspecificnatureofthetest.
CA水平不应该被作为单独的因素用于确定囊肿是否是恶性的。尽管很高的CA值可用于辅助诊断,但是,由于检测的非特异性本质,CA水平正常并不能排除卵巢癌的可能。
CAwasfirstdescribedbyBastin.19CAiswidelydistributedinadulttissues.Aroutinelyusedcut-offvalueof35iu/mlisbaseduponthedistributionofvaluesin99%ofhealthymenandwomen.20
年,CA首次被Bast描述出来。19CA广泛分布于成人组织中。根据例中99%的健康男性和女性的值分布,其常规使用的临界值为35iu/ml。
TheuseofserumCAiswellestablished,beingraisedinover80%ofepithelialovariancancercases,butnotinmostprimarymucinousovariancancers.20,56–59Ifacut-offof30iu/mlisused,thetesthasasensitivityof81%andspecificityof75%.28
血清CA的使用是公认的,超过80%例上皮性卵巢癌患者CA升高,但是大多数原发性卵巢粘液性癌患者的CA没有此改变。20,56–59如果临界值降为30iu/ml,那么,该检测的敏感性为81%,特异性为75%。28
However,CAvaluescanshowwidevariation,withlowerlevels(20iu/ml)foundinhealthypostmenopausalwomen.21,22,33,34
然而,CA值可以呈现出很大的差异性,健康的绝经后妇女CA低水平(20iu/ml)。21,22,33,34
Non-malignantgynaecologicalconditionssuchaspelvicinflammatorydisease,fibroids,acuteeventsinbenigncysts(e.g.torsionorhaemorrhage)andendometriosiscanallresultinanincreasedCAlevel.35,36HighervaluesarereportedinCaucasian治疗白癜风多少钱白癜风医院好不好